The Mouth-Heart Connection

Aging and Oral Health

What You Need to Know About Apical Periodontitis and Cardiovascular Disease

Can a dental infection influence your heart health? According to a new umbrella review published in the Journal of Dentistry, the answer might be yes. The study, led by Talekar et al. (2025), dives into the possible link between apical periodontitis (AP)—a common dental infection—and cardiovascular diseases, the world’s leading cause of death.

By synthesizing data from 10 systematic reviews, this umbrella review represents one of the most comprehensive looks at how these two seemingly unrelated health issues might be connected.

Here are the top five takeaways you need to know:

1. Gum Disease May Significantly Increase Cardiovascular Risk

The study found that individuals with apical periodontitis are at a 32% higher relative risk and 83% higher odds of developing cardiovascular diseases. This includes coronary artery disease, stroke, and other major vascular conditions. While this doesn’t prove causation, it strongly suggests AP is more than just a local dental problem—it could be a systemic red flag.

2. Inflammation Is the Common Thread

The biological plausibility of this link centers around chronic inflammation. AP leads to a persistent inflammatory response, which can spill over into the bloodstream. This low-grade, systemic inflammation may accelerate atherosclerosis, the buildup of plaque in arteries—a key driver of cardiovascular disease.

3. Evidence Is Consistent, but Not Without Limitations

The umbrella review highlights high heterogeneity among studies. This means differences in study design, population size, and diagnostic methods make it hard to establish a clear-cut cause-and-effect relationship. Still, the consistency gives the association credibility.

4. Current Clinical Guidelines Don’t Yet Reflect This Risk

Despite the growing evidence, most cardiovascular risk assessments don’t account for oral health status—particularly gum disease. Incorporating dental screening into cardiovascular disease management, especially for patients with unexplained or resistant cardiovascular symptoms.

5. More High-Quality Research Is Needed

The study calls for large, prospective cohort studies with standardized AP definitions and better confounder control. This will help clarify the “dose-response” relationship—i.e., does the severity or duration of gum disease matter? And can effective root canal treatments reduce cardiovascular disease risk?

Final Thoughts: The Tooth-Heart Connection Deserves More Attention

This umbrella review reinforces an important but often overlooked concept: your mouth is not separate from the rest of your body. Apical periodontitis, while common and often symptomless, might be a silent contributor to cardiovascular disease—the world’s leading killer.

Oral health assessments should be part of a comprehensive cardiovascular evaluation. And for the rest of us, it’s another reason not to skip those dental checkups. After all, taking care of your teeth might just help protect your heart.

Contact Us

If you haven't seen a Dentist in a while, don't worry. You can make an appointment to see Dr. Esfandiari and get back on track with your preventative dental health care. Call the Ventura office to make an appointment 805-647-6100 or click here to make an appointment online.

Take A Tour

We've launched a video for you to see what's inside our Ventura offices. When choosing a dentist we know it's important to feel safe, comfortable and familiar with your surroundings. 



Navigating Dental Anxiety: Tips for a Stress-Free Visit

dental anxiety

Navigating Dental Anxiety: Tips for a Stress-Free Visit

Dental anxiety is a common issue that affects many people. The thought of sitting in the dentist’s chair can trigger fear and stress, making it easy to put off important dental visits. However, taking care of your oral health is crucial. Here are five effective strategies to help you navigate dental anxiety and ensure a stress-free visit.

1. Communicate with Dr. Esfandiari:

Open communication is key to alleviating anxiety. Before your appointment, take the time to discuss your fears with Dr. Esfandiari. He'll explain the procedures in detail, answer your questions, and address any specific concerns you might have. Knowing what to expect can significantly reduce your anxiety and help you feel more in control.

2. Practice Relaxation Techniques

Incorporating relaxation techniques into your routine can help calm your nerves before and during your visit. Consider trying deep breathing exercises, progressive muscle relaxation, or mindfulness meditation. A few minutes of focused breathing or visualization can make a significant difference in your anxiety levels. Arriving at the office a bit early can give you time to practice these techniques and gather your thoughts.

3. Bring a Support Person: 

Having a friend or family member accompany you to your appointment can provide emotional support and comfort. They can help distract you during the procedure and offer reassurance. If you're feeling particularly anxious, ask your companion to engage you in conversation or bring along music or an audiobook to help take your mind off the treatment.

4. Explore Sedation Techniques:

If your anxiety is severe, consider discussing sedation options with Dr. Esfandiari. Many dental offices offer various forms of sedation, including nitrous oxide (laughing gas), oral sedatives, or even IV sedation. These methods can help you relax during your procedure and ensure you have a more comfortable experience.  Dr. Esfandiari will work with you to determine the best option based on your needs.

5. Focus on the Benefits of Dental Care:

Remind yourself of the positive outcomes that come with regular dental visits. A healthy smile boosts your confidence and contributes to your overall well-being. Think about the long-term benefits of maintaining good oral health, such as preventing cavities and gum disease. Setting goals, such as improving your smile or reducing pain, can help motivate you to face your fears and prioritize your dental health.


Dental anxiety is manageable with the right strategies and support. By communicating openly, practicing relaxation techniques, bringing a companion, exploring sedation options, and focusing on the benefits of dental care, you can transform your dental visits from a source of stress into an opportunity for self-care. Remember, taking care of your teeth is an essential part of taking care of yourself. Don’t hesitate to reach out to your dentist for additional support and guidance. Your smile deserves it!

Make an Appointment with Dr. Esfandiari 

If you haven't seen a Dentist in a while, don't worry. You can make an appointment to see Dr. Esfandiari and get back on track with your preventative dental health care. Call the Ventura office to make an appointment 805-647-6100 or click here to make an appointment online.

Take A Tour

We've launched a video for you to see what's inside our Ventura office. When choosing a dentist we know it's important to feel safe, comfortable and familiar with your surroundings.